header-top

Molecular diagnostics in the palm of your hand

Overview

Powerful platforms for disease detection.

The INSPECTR™ platform enables the creation of instrument-free, simple-to-operate diagnostic tests that can be applied across multiple diseases and used in a variety of settings. INSPECTR can be adapted to work on a simple paper strip test or to provide an electrochemical readout that can be read with a mobile phone. It can also be adapted for use in laboratory or point-of-care settings. By decentralizing testing, INSPECTR has the potential to dramatically change health outcomes for people all over the world, mitigating the spread of disease and helping patients make vital health decisions sooner.

Engineering Biology INSPECTR for SARS-CoV-2

Listen to our CTO William Blake discuss INSPECTR

texture-block

What is INSPECTR™?

INSPECTR leverages the power of synthetic biology by using freeze-dried synthetic gene networks as programmable molecular diagnostic devices. The INSPECTR platform enables the creation of instrument-free, simple-to-operate diagnostic tests that can be applied across multiple diseases and used in a variety of settings. INSPECTR stands for Internal Splint-Pairing Expression Cassette Translation Reaction.

A synthetic biology-based molecular diagnostics platform, INSPECTR was developed by our founders and is licensed exclusively from the Wyss Institute of Harvard University. INSPECTR can be programmed to distinguish targets based on a single nucleotide without an instrument and at room temperature. When INSPECTR’s synthetic biosensors detect the presence of a nucleic acid target, a reporter protein is produced. This protein output can be designed to generate a signal tailored to any medium, providing a simple diagnostic readout. This novel approach enables the rapid development of molecular diagnostic tests that are low cost, easy-to-use and broadly applicable.

Performance and Attributes

Sherlock’s unique Engineering Biology platform advantages span virtually every important category of performance:

  • Highly sensitive (can detect a single molecule in a sample)
  • Highly specific (accurately detects the target)
  • Integrates well with other tests and lab setups
  • Quantitative (measures amount of target present)
  • Rapid design and delivery to partners

In addition, Sherlock’s technologies have advantages that can create value for existing and new applications. Sherlock’s platforms also deliver the following important attributes:

  • Portable (can be used in many different settings)
  • Native specimen testing (direct analysis of unprocessed samples)
  • Rapid (results in under one hour)
  • Low cost
Top